李春艳导师主页
基本信息
姓名: 李春艳
职称: 副教授
单位电话:
电子信箱: lichunyan79@sina.com
办公室: 化学化工大楼A311
个人主页:
个人简介

李春艳,女,博士,副教授。主要从事有机小分子探针的设计、合成及在生化分析中的应用研究。目前主持国家自然科学基金,湖南省自然科学基金项目,中国博士后基金,湖南省教育厅项目国家重点实验室开放课题,教育部重点实验室开放课题等项目共11项。近年来,已在以第一作者或通讯作者在Analytical  ChemistryChemical  CommunicationAnalytica  Chimica  ActaSensors  and  Actuators  BDyes  and  Pigments等国际刊物发表论文30,被他人引用数已超过800。获得授权的发明专利2项。已培养研究生18人,毕业12,在读6其中4人获湘潭大学研究生校长奖4获硕士研究生国家奖学金。


学习工作经历

20089月至今 湘潭大学化学学院工作

20139月至20149月 美国伊利诺伊大学香槟分校访问学者

20137月至20165月 湘潭大学博士后

20059月至20087月 于湖南大学获博士学位

20029月至20057月 于湖南大学获硕士学位

19989月至20027月 于河南师范大学获学士学位

主讲课程

主讲课程:分析化学,光谱分析,色谱分析

研究方向

有机小分子荧光探针的设计合成,荧光探针在生化分析中的应用

科研项目

承担项目(主持

[1] 国家自然科学基金面上项目,基于缺氧诱导释放的近红外诊疗探针的构建及其初步生物医学应用研究2018-2021在研

[2] 国家自然科学基金青年项目,基于能量转移机理的蛋白激酶比率荧光分子探针的设计合成及生物医学应用,2011-2013已结题

[3] 湖南省自然科学基金项目青年人才培养基金,定位线粒体的比率型三磷酸腺苷荧光探针的研究2015-2017在研

[4] 湖南省自然科学基金项目面上项目,能量转移型蛋白激酶荧光探针的研究,2011-2013已结题

[5] 中国博士后科学基金特别资助项目,定位线粒体的比率型荧光探针的研究,2015-2016已结题

[6] 中国博士后科学基金面上项目,能量转移型荧光探针的研究2014-2016已结题

[7] 湖南省教育厅优秀青年项目,用于三磷酸腺苷定位和检测的双功能比率荧光探针的构建及细胞成像研究2016-2018在研。

[8] 湖南省教育厅一般项目,能量转移型蛋白激酶荧光探针的研究,2011-2013已结题

[9] 化学生物传感与计量学国家重点实验室(湖南大学)开放基金,定位细胞器的比率型荧光探针的研究,2016-2017在研

[10] 化学生物传感与计量学国家重点实验室(湖南大学)开放基金,预组织自剪切型酶荧光探针的研究,2010-2012已结题

[11] 环境友好化学与应用教育部重点实验室(湘潭大学)开放课题,环境中重金属离子识别的荧光超分子探针受体分子库的建立及筛选研究,2010-2012已结题

[12] 湘潭大学科研启动项目,新型荧光探针的设计、合成及在氨基酸测定中的应用,2009-2011已结题

 

发明专利

授权专利

[1] 李春艳,吴银双,李勇飞,一种基于芘的铜离子比率型荧光探针及其制备方法和应用,2016.09.07,中国专利,ZL201410846656.5

[2] 李春艳,孔雪飞,李勇飞,一种铬离子比率型荧光探针及其制备方法和应用,2015.01.14,中国专利,ZL201310322506.X

 

代表性学术成果

发表论文(第一作者或通信联系人)

[1] Song-Jiao Li, Chun-Yan Li*, Yong-Fei Li, Junjie Fei, Ping Wu, Bin Yang, Juan Ou-Yang, Shi-Xin Nie, A facile and sensitive near-infrared fluorescence probe for the detection of endogenous alkaline phosphatase activity in vivo. Analytical Chemistry, 2017, 89, 6854-6860. (IF: 6.320)

[2] Kai-Yue Tan, Chun-Yan Li*, Yong-Fei Li, Junjie Fei, Bin Yang, Ya-Jun Fu, Fang Li. Real-time monitoring ATP in mitochondrion of living cells: a specific fluorescent probe for ATP by dual recognition sites. Analytical Chemistry, 2017, 89, 1749-1756. (IF: 6.320)

[3] Jun-Ying Xie, Chun-Yan Li*, Yong-Fei Li, Junjie Fei, Fen Xu, Juan Ou-Yang, Juan Liu. Near-infrared fluorescent probe with high quantum yield and its application in the selective detection of glutathione in living cells and tissues. Analytical Chemistry, 2016, 88, 9746-9752. (IF: 6.320)

[4] Jia-Liang Tang, Chun-Yan Li*, Yong-Fei Li, Chun-Xiang Zou. A ratiometric fluorescent probe with unexpected high selectivity for ATP and its application in cell imaging. Chemical Communications, 2014, 50, 15411-15414. (IF: 6.319)

[5] Chun-Yan Li, Xiao-Bing Zhang, Li Qiao, Yan Zhao, Chun-Mei He, Shuang-Yan Huan, Li-Min Lu, Li-Xin Jian, Guo-Li Shen, Ru-Qin Yu. Naphthalimide-porphyrin hybrid based ratiometric bio-imaging probe for Hg2+: well-resolved emission spectra and unique specificity. Analytical Chemistry, 2009, 81, 9993-10001. (IF: 6.320)

[6] Juan Ou-Yang, Chun-Yan Li*, Yong-Fei Li, Junjie Fei, Fen Xu, Song-Jiao Li, Shi-Xin Nie. A rhodamine-based fluorescent probe with high water solubility and its application in the detection of glutathione with unique specificity. Sensors and Actuators B: Chemistry, 2017, 240, 1165-1173. (IF: 5.401)

[7] Ya-Jun Fu, Zhi Li, Chun-Yan Li*, Yong-Fei Li*, Ping Wu, Zuo-Heng Wen. Borondipyrrolemethene-based fluorescent probe for distinguishing cysteine from biological thiols and its application in cell image. Dyes and Pigments, 2017, 139, 381-387. (IF: 3.473)

[8] Jun-Ying Xie, Chun-Yan Li*, Yong-Fei Li, Ya-Jun Fu, Shi-Xin Nie, Hong-Yan Tan. A near-infrared chemosensor for determination of trivalent aluminum ions in living cells and tissues. Dyes and Pigments, 2017, 136, 817-824. (IF: 3.473)

[9] Dan Li, Chun-Yan Li*, Yong-Fei Li, Zhi Li, Fen Xu. Rhodamine-based chemodosimeter for fluorescent determination of Hg2+ in 100% aqueous solution and in living cells. Analytica Chimica Acta, 2016, 934, 218-225. (IF: 4.950)

[10] Dan Li, Chun-Yan Li*, Hong-Rui Qi , Kai-Yue Tan, Yong-Fei Li. Rhodamine-based chemosensor for fluorescence determination of trivalent chromium ion in living cells. Sensors and Actuators B: Chemistry, 2016, 223, 705-712. (IF: 5.401)

[11] Yin-Shuang Wu, Chun-Yan Li*, Yong-Fei Li, Dan Li, Zhi Li. Development of a simple pyrene-based ratiometric fluorescent chemosensor for copper ion in living cells. Sensors and Actuators B: Chemistry, 2016, 222, 1226-1232. (IF: 5.401)

[12] Jia-Liang Tang, Chun-Yan Li*, Yong-Fei Li, Xi Lu, Hong-Rui Qi. A highly sensitive and selective fluorescent probe for trivalent aluminum ion based on rhodamine derivative in living cells. Analytica Chimica Acta, 2015, 888 ,155-161. (IF: 4.950)

[13] Chun-Yan Li*, Xue-Fei Kong, Yong-Fei Li, Chao Weng, Jia-Liang Tang, Dan Liu, Wei-Guo Zhu. Ratiometric near-infrared chemosensor for trivalent chromium ion based on tricarboyanine in living cells. Analytica Chimica Acta, 2014, 824, 71-77. (IF: 4.950)

[14] Yin-Shuang Wu, Chun-Yan Li*, Yong-Fei Li, Jia-Liang Tang, Dan Liu. A ratiometric fluorescent chemosensor for Cr3+ based onmonomer-excimer conversion of a pyrene compound. Sensors and Actuators B: Chemical, 2014, 203, 712-718. (IF: 5.401)

[15] Chun-Yan Li*, Chun-Xiang Zou, Yong-Fei Li, Jia-Liang Tang, Chao Weng. A new rhodamine-based fluorescent chemosensor for Fe3+ and its application in living cell imaging. Dyes and Pigments, 2014, 104, 110-115. (IF: 3.473)

[16] Chun-Yan Li*, Chun-Xiang Zou, Yong-Fei Li, Xue-Fei Kong, Yu Zhou, Yin-Shuang Wu, Wei-Guo Zhu. A colormetric and fluorescent chemosensor for adenosine-5’-triphosphate based on rhodamine derivative. Analytica Chimica Acta, 2013, 795, 69-74. (IF: 4.950)

[17] Chun-Yan Li*, Yu Zhou, Yong-Fei Li, Xue-Fei Kong, Chun-Xiang Zou, Chao Weng. Colorimetric and fluorescent chemosensor for citrate based on a rhodamine and Pb2+ complex in aqueous solution. Analytica Chimica Acta, 2013, 774, 79-84. (IF: 4.950)

[18] Chun-Yan Li*, Yu Zhou, Yong-Fei Li, Chun-Xiang Zou, Xue-Fei Kong. Efficient FRET-based colorimetric and ratiometric fluorescent chemosensor for Al3+ in living cells. Sensors and Actuators B, 2013, 186, 360-366. (IF: 5.401)

[19] Chun-Yan Li*, Xue-Fei Kong, Yong-Fei Li, Chun-Xiang Zou, Dan Liu, Wei-Guo Zhu. Ratiometric and colorimetric fluorescent chemosensor for Ag+ based on tricarbocyanine. Dyes and Pigments, 2013, 99, 903-907. (IF: 3.473)

[20] Chun-Yan Li*, Yu Zhou, Yong-Fei Li, Chun-Xiang Zou, Xue-Fei Kong. A fluorescent chemosensor for Hg2+ based on a rhodamine derivative in an aqueous solution. Analytical Sciences, 2013, 29, 899-903. (IF: 1.228)

[21] Chun-Yan Li*, Fen Xu, Yong-Fei Li, Kai Zhou, Yu Zhou. A fluorescent chemosensor for Hg2+ based on naphthalimide derivative by fluorescence enhancement in aqueous solution. Analytica Chimica Acta, 2012, 717, 122-126. (IF: 4.950)

[22] Chun-Yan Li*, Yu Zhou, Fen Xu, Yong-Fei Li, Chun-Xiang Zou, Chao Weng. A fluorescent pH chemosensor based on functionalized naphthalimide in aqueous solution. Analytical Sciences, 2012, 28, 743-747. (IF: 1.228)

[23] Yong-Fei Li, Chun-Yan Li*, Fen Xu, Yu Zhou, Qi-Chang Xiao. A fluorescent chemosensor for cysteine based on naphthalimide derivative in aqueous solution. Sensors and Actuators B: Chemical, 2011, 155, 253-257. (IF: 5.401)

[24] Chun-Yan Li*, Fen Xu, Yong-Fei Li. A fluorescent chemosensor for silver ions based on porphyrin compound with high selectivity. Spectrochimica Acta Part A, 2010, 76, 197-201. (IF: 2.536)

[25] Chun-Yan Li, Xiao-Bing Zhang, Yan-Yan Dong, Qiu-Juan Ma, Zhi-Xiang Han, Yan Zhao, Guo-Li Shen, Ru-Qin Yu. A porphyrin derivative containing 2-(oxymethyl)pyridine units showing unexpected ratiometric fluorescent recognition of Zn2+ with high selectivity. Analytica Chimica Acta, 2008, 616, 214-221. (IF: 4.950)

[26] Chun-Yan Li, Xiao-Bing Zhang, Zhen Jin, Rui Han, Guo-Li Shen, Ru-Qin Yu. A fluorescent chemosensor for cobalt ions based on a multi-substituted phenol-ruthenium (II) tris(bipyridine) complex. Analytica Chimica Acta, 2006, 580, 143-148. (IF: 4.950)

[27] Chun-Yan Li, Xiao-Bing Zhang, Zhi-Xiang Han, Bjorn Akermark, Licheng Sun, Guo-Li Shen, Ru-Qin Yu. A wide pH range optical sensing system based on a sol-gel encapsulated amino-functionalisedcorrole. Analyst, 2006, 131, 388-393. (IF: 3.885)


研究生培养

[1] 在读硕士生:欧阳娟,李宋娇,江文丽,周东叶,赵仪婷,田杨

[2] 已毕业硕士生:谢俊英(国家奖学金,校长奖),谭凯月,付雅俊,吴银双(国家奖学金),李丹,李芝,唐佳良(国家奖学金),卢曦,邹春香(国家奖学金),孔雪飞(校长奖),周雨(校长奖),徐芬(校长奖)