张雪飞导师主页
基本信息
姓名: 张雪飞
职称: 教授
单位电话:
电子信箱: zxf7515@163.com
办公室: 高分子教研室
个人主页:
个人简介

毕业于中国科学院长春应用化学所,一直从事生物医用可降解高分子材料合成及应用的研究工作。先后在《Biomaterials》、《Journal of Controlled Release》、《Biomacromolecules》等国际期刊发表相关SCI收录论文20多篇,参编专著一部,申请中国专利11项,已授权6项。自2005年以来,主持的科研项目共有9项,国家级4项,省级4项,校级2项。目前在研国家自然科学基金2项:基于多药协同作用和逆转肿瘤耐药性的纳米药物载体的设计和构筑(国家自然科学基金面上项目);具有靶向和量子点示踪功能的水溶性聚酯高分子键合药研究(国家自然科学基金面上项目)。

个人简介

毕业于中国科学院长春应用化学所,一直从事生物医用可降解高分子材料合成及应用的研究工作。先后在《Biomaterials》、《Journal of Controlled Release》、《Biomacromolecules》等国际期刊发表相关SCI收录论文20多篇,参编专著一部,申请中国专利11项,已授权6项。自2005年以来,主持的科研项目共有9项,国家级4项,省级4项,校级2项。目前在研国家自然科学基金2项:基于多药协同作用和逆转肿瘤耐药性的纳米药物载体的设计和构筑(国家自然科学基金面上项目);具有靶向和量子点示踪功能的水溶性聚酯高分子键合药研究(国家自然科学基金面上项目)。

发明专利

1张雪飞,麻戈军,含侧羟基或含侧羧基官能团的聚丙交酯及其制备方法 ,中国发明专利,申请号:201310181259.6

2张雪飞,麻戈军,一种聚ε-己内酯负载的抗肿瘤前药及其制备方法,中国发明专利,申请号:201310179788.2

3张雪飞,麻戈军,一种聚丙交酯负载的前药及其制备方法 ,中国发明专利,申请号: 201310181055.2

4张雪飞,傅金燕,钟冠群,张海良,一种结构精确的新型两亲性聚合物为载体的抗肿瘤前药及合成方法。中国发明专利,专利号:ZL 200810143664.8(已授权)

5张雪飞,段谆谆,钟冠群,张海良,一种新型两亲性超支化聚酯为载体的抗肿瘤前药及制备方法。中国发明专利,专利号:ZL 200810143665.2(已授权)

6张雪飞,曾亮,一种基于纳米羟基磷灰石的生物活性材料及制备方法。中国发明专利,专利号:ZL 200910227126.1(已授权)

7张雪飞,付军,张力,钟冠群,张海良,一种基于甘油为支化单元的新型两亲性聚酯型树枝状大分子为载体的抗肿瘤前药及制备方法。中国发明专利,申请号:200910043525.2

8张雪飞,张英伟,王海波,钟冠群,张海良,一种基于苹果酸为支化单元的新型两亲性树枝状大分子为载体的抗肿瘤前药及制备方法。中国发明专利,申请号: 200910043524.8

9景遐斌,张雪飞,陈学思,徐效义,胡俊丽,载有胰岛素的生物降解高分子微球及其制备方法。中国发明专利,专利号:ZL 200410010735.9(已授权)

10景遐斌,张雪飞,陈学思,徐效义,梁奇志,边新超,杨立新,可生物降解聚合物的紫杉醇前药及其合成方法。中国发明专利,专利号:ZL 200410011176.3(已授权)

11景遐斌,张雪飞,陈学思,徐效义,胡俊丽,边新超,杨立新,载有紫杉醇的可生物降解高分子纳米微球及制备方法。中国发明专利,申请号:200410010733.X

12郭建辉,张雪飞,聚乙二醇为载体的紫杉醇或多烯紫杉醇的前药。中国发明专利,专利号:ZL 200510027736.9(已授权)

 

发明专利

 

1张雪飞,麻戈军,含侧羟基或含侧羧基官能团的聚丙交酯及其制备方法 ,中国发明专利,申请号:201310181259.6

2张雪飞,麻戈军,一种聚ε-己内酯负载的抗肿瘤前药及其制备方法,中国发明专利,申请号:201310179788.2

3张雪飞,麻戈军,一种聚丙交酯负载的前药及其制备方法 ,中国发明专利,申请号: 201310181055.2

4张雪飞,傅金燕,钟冠群,张海良,一种结构精确的新型两亲性聚合物为载体的抗肿瘤前药及合成方法。中国发明专利,专利号:ZL 200810143664.8(已授权)

5张雪飞,段谆谆,钟冠群,张海良,一种新型两亲性超支化聚酯为载体的抗肿瘤前药及制备方法。中国发明专利,专利号:ZL 200810143665.2(已授权)

6张雪飞,曾亮,一种基于纳米羟基磷灰石的生物活性材料及制备方法。中国发明专利,专利号:ZL 200910227126.1(已授权)

7张雪飞,付军,张力,钟冠群,张海良,一种基于甘油为支化单元的新型两亲性聚酯型树枝状大分子为载体的抗肿瘤前药及制备方法。中国发明专利,申请号:200910043525.2

8张雪飞,张英伟,王海波,钟冠群,张海良,一种基于苹果酸为支化单元的新型两亲性树枝状大分子为载体的抗肿瘤前药及制备方法。中国发明专利,申请号: 200910043524.8

9景遐斌,张雪飞,陈学思,徐效义,胡俊丽,载有胰岛素的生物降解高分子微球及其制备方法。中国发明专利,专利号:ZL 200410010735.9(已授权)

10景遐斌,张雪飞,陈学思,徐效义,梁奇志,边新超,杨立新,可生物降解聚合物的紫杉醇前药及其合成方法。中国发明专利,专利号:ZL 200410011176.3(已授权)

11景遐斌,张雪飞,陈学思,徐效义,胡俊丽,边新超,杨立新,载有紫杉醇的可生物降解高分子纳米微球及制备方法。中国发明专利,申请号:200410010733.X

12郭建辉,张雪飞,聚乙二醇为载体的紫杉醇或多烯紫杉醇的前药。中国发明专利,专利号:ZL 200510027736.9(已授权)

 

论文专著

1.       (Methoxy-Poly(ethylene glycol)-block-Poly(ε-caprolactone) Bearing Pendant Aldehyde Groups as pH-Responsive Drug Delivery Carrier). Australian Journal of Chemistry 2013, 66(12), 1576-1583. Gejun Ma, Deshan Li, Ji Wang,*Xuefei Zhang, *Haoyu Tang

2.       pH-Triggered Charge-Reversal Polypeptide Nanoparticles for Cisplatin Delivery: Preparation and In Vitro Evaluation. BIOMACROMOLECULES, 2013,14(6), 2023-2032, Huang Yue, *Tang, Zhaohui, *Zhang, Xuefei, Yu Haiyang, Sun Hai, Pang  Xuan, Chen Xuesi

3.       Synthesis and characterization of a novel biodegradable amphiphilic MPEG-dendritic block copolymer containing (glycolic acid)-alt-(lactic acid) oligomer and glycerol. Journal of Controlled Release, 2011,152: e264-e266. Jianwei Jiang, Li Zhang, Miao Wu, Xuefei Zhang*

4.       Synthesis and Characterization of a Well-Defined Amphiphilic Block Copolymer and Its Paclitaxel Prodrug from Methoxy Poly(ethylene glycol) and Oligomer of Glycolic Acid. Journal of Applied Polymer Science, 2011, 758-766. Li Zhang, Jinyan Fu, Zhixiang Xia, Ping Wu, Xuefei Zhang*

5.       Synthesis and Characterization of a Novel Biodegradable Amphiphilic Dendritic Polyether-ester. Australian Journal of Chemistry. 2012, 65, 545–551, Jin peng Xiao, Hong Wang, Qiang Yi, Gejun Ma,  Xue fei Zhang*

6.       A new approach for synthesis of the comb-shaped poly (e-caprolactone) brushes on the surface of nano-hydroxyapatite by combination of ATRP and ROP, Journal of Colloid and Interface Science, 2010, 352: 36-42. Liang Zeng, Haibo Wang, Guoxin Fu , Jianwei Jiang, Xuefei Zhang*

7.       Fabrication and characterization of nanocomposites with high-impact polystyrene and hydroxyapatite with well-defined polystyrene via ATRP. Journal of Reinforced Plastics and Composites , 2011, 30 , 1445-1453. Guoxin Fu, Zhixiang Xia, Jianwei Jiang, Bo Jing, Xuefei Zhang *

8.       Preparation and Characterization of Nanocomposites based on Poly (ε-caprolactone) and the Surface Grafted Nanohydroxyapatite with the Comb-shaped Poly (ε-caprolactone) Brushes, Polymers and Polymer Composites, 2012, 20,463-469 . Guoxin Fu, Liang Zeng, Jianwei Jiang, Zhixiang Xia, Bo Jing, Xuefei Zhang *

9.       A novel amphotropic polymer based on cellulose nanocrystals grafted with azo polymers, European Polymer Journal, 2008, 44, 28302837. Qunxing Xu , Jie Yi , Xuefei Zhang , Hailiang Zhang,

10.   Chiral-nematic self-ordering of rodlike cellulose nanocrystals grafted with poly(styrene) in both thermotropic and lyotropic states, Polymer, 2008, 49, 44064412. Jie Yi, Qunxing Xu , Xuefei Zhang, Hailiang Zhang.

11.   Design, Synthesis, and Characterization of a Combined Main-Chain/Side-Chain Liquid Crystalline Polymer Based on Mesogen-Jacketed Liquid Crystal Polymer via Atom Transfer Radical Polymerization ,Journal of Polymer Science: Part A: Polymer Chemistry, 2008, 46, 73107320. Helou Xie, Tianhui Hu, Xuefei Zhang, Hailiang Zhang, Erqiang Chen, Qifeng Zhou.

12.   Synthesis and Characterization of a Novel Diblock Copolymer with a Polyrotoxane Block, Polymer Bulletin, 2008,61 , 53–62. Bin Ni, Xingzhu Wang, Huaguang Yu, Xuefei Zhang, Hailiang Zhang, Wai-Yeung Wong.

13.   Synthesis of Poly (ethylene oxide)-b-polystyrene-bpoly(4-vinylpyridine) ABC Triblock Copolymers by Two-step Atom Transfer Radical Polymerization, Iranian Polymer Journal, 2008,17, 781-790. Qizhen Xiao, Xuefei Zhang, Jie Yi, Xingzhu Wang, Hailiang Zhang.

14.   Temperature-induced chiral nematic phase changes of suspensions of poly(N,N-dimethylaminoethyl methacrylate)-grafted cellulose nanocrystals. Cellulose, 2009, 16, 989–997. Jie Yi, Qunxing Xu, Xuefei Zhang, Hailiang Zhang.

15.   Comparative study of paclitaxel physically encapsulated in and chemically conjugated with PEG-PLA. Polym. Adv. Technol. 2009, 20, 843–848. Xiaoyi Xu, Xuefei Zhang, Xiuhong Wang, Yuxin Li, Xiabin Jing.

16.   Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate, Biomaterials2005; 26: 21212128. Xuefei Zhang, Yuxin Li, Xuesi Chen, Xiuhong Wang, Xiaoyi Xu, Qizhi Liang, Junli Hu, Xiabin Jing.

17.   载有胰岛素的可生物降解微球的制备与表征,高等学校化学学报,2005;26: 554-557. 张雪飞, 胡俊丽, 陈学思, 景遐斌。

18.   Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulationJournal of Controlled Release, 2005; 105: 43-51. Jing Zeng, Lixin Yang, Qizhi Liang, Xuefei Zhang, Huili Guan, Xiuling Xu, Xuesi Chen and Xiabin Jing.

19.   Synthesis of a novel structural triblock copolymer of poly(γ -benzyl--glutamic acid)-b-poly(ethylene oxide)-b-poly(-caprolactone) Biomaterials2004; 25: 3553-3558. Mingxiao Deng, Rong Wang, Guangzhuo Rong , Jingru Sun , Xuefei Zhang, Xuesi Chen and Xiabin Jing.

20.   Stereoselective Polymerization of rac-Lactide Using a Monoethylaluminum Schiff Base ComplexBiomacromolecules, 2004; 5: 965-970. Tang, Z.; Chen, X.; Pang, X.; Yang, Y.; Zhang, X.; Jing, X.

21.   Stereoselective polymerization of rac-lactide with a bulky aluminum/Schiff base complexJournal of Polymer Science Part A: Polymer Chemistry 2004; 42: 5974-5982. Zhaohui Tang, Xuesi Chen, Yongkun Yang, Xuan Pang, Jingru Sun, Xuefei Zhang, Xiabin Jing.

22.   Synthesis of four-armed poly(-caprolactone)-block-poly(ethylene oxide) by diethylzinc catalystJournal of Polymer Science Part A: Polymer Chemistry 2004; 42: 950-959. Mingxiao Deng, Xuesi Chen, Longhai Piao, Xuefei Zhang, Zhongli Dai, Xiabin Jing.

Probing the micellization of diblock and triblock copolymers of poly(l-lactide) and poly(ethylene glycol) in aqueous and NaCl salt solutions Colloid & Polymer Science 2004; 282: 343 – 350. Zhongli Dai, Longhai Piao, Xuefei Zhang, Mingxiao Deng, Xuesi Chen and Xiabin Jin.